Nitrofurazone: Reproductive Assessment by Continuous Breeding in Swiss Mice
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چکیده
منابع مشابه
Nitrofurazone: reproductive assessment by continuous breeding in Swiss mice.
Nitrofurazone (NTFZ), a nitrofuran antibiotic, was evaluated for reproductive toxicity in Swiss CD-1 mice using the Reproductive Assessment by Continuous Breeding protocol. Male and female mice were cohabited for 15 weeks and exposed to NTFZ in feed at concentrations of 0, 100, 375, and 750 ppm (14-102 mg/kg/day). Fzero 750-ppm breeding pairs had significantly reduced fertility after 7 days of ...
متن کاملReproductive toxicology. Nitrofurazone.
Nitrofurazone (NF), part of a large and clinically useful class of antibacterial nitroaro-matic agents, was tested for its effects on reproduction and fertility in Swiss CD-1 mice using the RACB protocol. Data from a 2-week dose-range-finding study (Task 1) were used to set exposure concentrations for the Task 2 continuous cohabitation study at 100, 375, and 750 ppm in feed. Measures of food co...
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The reproductive toxicity of ethylene glycol monoethyl ether (EGEE) was evaluated in the Fertility Assessment by Continuous Breeding protocol. Both male and female CD-1 mice were given 0, 0.5, 1.0 or 2% EGEE in the drinking water and were housed as breeding pairs continuously for 14 weeks. Significant adverse effects on fertility were seen at 1 and 2% but not at 0.5%. After the continuous breed...
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The Reproductive Assessment by Continuous Breeding (RACB) design has been used by the National Toxicology Program for approximately 15 years. This article details the evolutions in the thinking behind the design and the end points used in the identification of hazards to reproduction. Means of nominating chemicals are provided, and both early and current designs are described as well as some pr...
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Many biological databases that provide comparative genomics information and tools are now available on the internet. While certainly quite useful, to our knowledge none of the existing databases combine results from multiple comparative genomics methods with manually curated information from the literature. Here we describe the Princeton Protein Orthology Database (P-POD, http://ortholog.prince...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 1996
ISSN: 1096-6080,1096-0929
DOI: 10.1093/toxsci/34.1.56